| Syllabus: GS-III  Subject: Science & Technology  Topic: Medical science and Health, Issue: TB Care. |
Context: Randomised Control trials(RCT) transformed Tuberculosis(TB) treatment.
Randomized Control Trials(RCT):
In an RCT, participants are randomly assigned to one of two or more groups:
- An intervention group: This group receives the new treatment or approach being studied.
- A control group: This group receives the standard treatment or a placebo (an inactive substance).
- By comparing the outcomes of the two groups, researchers can determine whether the new treatment is safe and effective.
- Streptomycin is the first effective antibiotic for TB.
- Sir Austin Bradford Hill’s RCT implementation,optimized streptomycin dosage and regimen.
- RCT success in TB treatment set the standard for clinical trials across medical fields.
Prelims Connect(Diseases in news)
| Tuberculosis (TB):
·      TB is caused by Mycobacterium tuberculosis, primarily affecting the lungs. ·      Spread occurs through the air via coughing, sneezing, or spitting. ·      Symptoms include chronic cough, blood-containing mucus, fever, night sweats, and weight loss. ·      Treatable with antibiotics, but drug-resistant forms are challenging. ·      World Health Organisation recognizes TB as a major global health issue, focusing on improved diagnostics, treatments, and vaccines. |
