Randomised control trials: the technique that transformed TB care.

Syllabus: GS-III  Subject: Science & Technology  Topic: Medical science and Health, Issue: TB Care.

Context: Randomised Control trials(RCT) transformed Tuberculosis(TB) treatment.

Randomized Control Trials(RCT):

In an RCT, participants are randomly assigned to one of two or more groups:

  • An intervention group: This group receives the new treatment or approach being studied.
  • A control group: This group receives the standard treatment or a placebo (an inactive substance).
  • By comparing the outcomes of the two groups, researchers can determine whether the new treatment is safe and effective.
  • Streptomycin is the first effective antibiotic for TB.
  • Sir Austin Bradford Hill’s RCT implementation,optimized streptomycin dosage and regimen.
  • RCT success in TB treatment set the standard for clinical trials across medical fields.

Prelims Connect(Diseases in news)

Tuberculosis  (TB):

·       TB is caused by Mycobacterium tuberculosis, primarily affecting the lungs.

·       Spread occurs through the air via coughing, sneezing, or spitting.

·       Symptoms include chronic cough, blood-containing mucus, fever, night sweats, and weight loss.

·       Treatable with antibiotics, but drug-resistant forms are challenging.

·       World Health Organisation recognizes TB as a major global health issue, focusing on improved diagnostics, treatments, and vaccines.

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